Stuart Kim (aging, biology, lifespan)

quick watch 9:19 

How and Why We Age with Stuart Kim
https://www.youtube.com/watch?v=Ir9gngv8BvY
https://www.youtube.com/watch?v=Ir9gngv8BvY
Stanford Alumni
Published on Apr 2, 2014

elt-3 transcription factor 
transcription factor 
elt

accumulated damage model (rusted car)

two models for aging
   rusted car (damage accumulation)
   brake and accelerator (genetic pathway)

regulation change
allowed for the possibility of rejuvination 
human skin and human kidney 

([ a longer version of the same talk ])
Stuart Kim - The Genetics of Aging
https://www.youtube.com/watch?v=lj9BXEyFryE
https://www.youtube.com/watch?v=lj9BXEyFryE
ideacity
Published on May 22, 2018
4:09

mice and fruitfly (science main research organism)

worm (live 2 weeks) 
three regulatory proteins
  ELT-5
  ELT-6
  ELT-3
regulatory protein is a transcription factor 
transcription factor regulates the expression of a whole bunch of downstream genes 
 ([ what are transcription factors?       ]) 
 ([ which genes are activated (expressed) ])   
the green - activating transcription factor 
 ([ turn on activating transcription factor  ]) 
 ([ tamp down repressive regulatory proteins ]) 
 delaying aging for a long long time 
 activator was no longer pressed down
 the repressor was pressed down too hard 
22:24  thank you very much 
i am a geneticist - geneticist go in and modulate the DNA 
we inhibited the gene for the brake 
we gave extra copy of the activator gene 
we clone the gene - we used recombinant DNA
we probably made them (the gene) in bacteria, took the DNA from the bacteria and put the DNA into the worm  
is it socially desire able to extend your lifespan 
scientifically we could this (delay aging), within our lifetime 

Transcription Factors [HD Animation]
  https://www.youtube.com/watch?v=OxJp1YQqqNo
  https://www.youtube.com/watch?v=OxJp1YQqqNo
  McGraw-Hill Animations
  Published on Jun 2, 2017

How Genes are Regulated: Transcription Factors
  https://www.youtube.com/watch?v=MkUgkDLp2iE
  https://www.youtube.com/watch?v=MkUgkDLp2iE
  Blair Lyons
  Published on Sep 30, 2011
  there are 1500 different types of transcription factors in human cells; they interact to create a complex language of gene expression 

DNA Transcription (Advanced)
  https://www.youtube.com/watch?v=SMtWvDbfHLo
  https://www.youtube.com/watch?v=SMtWvDbfHLo
  DNA Learning Center
  Published on Mar 22, 2010
  transcription initiation complex 
  activator proteins

Regulated Transcription
  https://www.youtube.com/watch?v=vi-zWoobt_Q
  https://www.youtube.com/watch?v=vi-zWoobt_Q
  ndsuvirtualcell
  Published on Jul 19, 2010
  this signal - often a protein
  the most common activation event for a protein in a signal pathway is the addition of a phosphate group. 
  mRNA production
  the transcription factor then binds to the DNA and moves to interact with the rest of the transcription protein complex, located at the transcription start site.  
  when the formation of this complex is complete, transcription of the gene will begin. 
  it is this sequence of events that ensures genes required for a specific tissue or only at a specific time  are expressed appropriately.

https://fareastgizmos.com/other_stuff/japanese-health-ministry-approves-world-first-trial-using-ips-cells-to-treat-spinal-cord-injuries.php
https://en.wikipedia.org/wiki/Induced_pluripotent_stem_cell